Ontology highlight
ABSTRACT:
SUBMITTER: Duch A
PROVIDER: S-EPMC5785523 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Duch Alba A Canal Berta B Barroso Sonia I SI García-Rubio María M Seisenbacher Gerhard G Aguilera Andrés A de Nadal Eulàlia E Posas Francesc F
Nature communications 20180125 1
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope with sudden increases of transcription while replicating. Here, we report the existence of a general mechanism for the protection of genomic integrity upon transcriptional outbursts in S phase that is mediated by Mrc1. The N-terminal phosphorylation of Mrc1 blocked replication and ...[more]