Ontology highlight
ABSTRACT:
SUBMITTER: Hjorth-Jensen K
PROVIDER: S-EPMC6182143 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Hjorth-Jensen Kim K Maya-Mendoza Apolinar A Dalgaard Nanna N Sigurðsson Jón O JO Bartek Jiri J Iglesias-Gato Diego D Olsen Jesper V JV Flores-Morales Amilcar A
Nucleic acids research 20181001 18
Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate that SPOP knockdown leads to spontaneous replication stress and impaired recovery from replication fork stalling. We show that this is associated with reduced expression of several key DNA repair and replicat ...[more]