Ontology highlight
ABSTRACT:
SUBMITTER: Michielsen LA
PROVIDER: S-EPMC5786830 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Michielsen Laura A LA Budding Kevin K Drop Daniël D van de Graaf Ed A EA Kardol-Hoefnagel Tineke T Verhaar Marianne C MC van Zuilen Arjan D AD Otten Henny G HG
Frontiers in immunology 20180122
Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and is considered to be involved in graft accommodation. Also, CD59 downregulates CD4+ and CD8+ T-cell activation and proliferation. It is unknown whether CD59 expression is affected by transplantation. The aim of this study was to evaluate the quantitative CD59 antigen expression ...[more]