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Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation.


ABSTRACT: Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and is considered to be involved in graft accommodation. Also, CD59 downregulates CD4+ and CD8+ T-cell activation and proliferation. It is unknown whether CD59 expression is affected by transplantation. The aim of this study was to evaluate the quantitative CD59 antigen expression on distinct leukocyte subsets following lung transplantation (n?=?26) and to investigate whether this differs from pretransplantation (n?=?9). The results show that CD59 expression on leukocytes is significantly lower posttransplantation compared with healthy controls (p?=?0.002) and pretransplantation (p?

SUBMITTER: Michielsen LA 

PROVIDER: S-EPMC5786830 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation.

Michielsen Laura A LA   Budding Kevin K   Drop Daniël D   van de Graaf Ed A EA   Kardol-Hoefnagel Tineke T   Verhaar Marianne C MC   van Zuilen Arjan D AD   Otten Henny G HG  

Frontiers in immunology 20180122


Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and is considered to be involved in graft accommodation. Also, CD59 downregulates CD4+ and CD8+ T-cell activation and proliferation. It is unknown whether CD59 expression is affected by transplantation. The aim of this study was to evaluate the quantitative CD59 antigen expression  ...[more]

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