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Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study.


ABSTRACT: Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.A two-sample MR approach was used to examine the causal effect of diet/lifestyle upon risk of T2DM and glycemic traits.The protein intake-increasing allele C of FTO was significant associated with higher risk of T2DM (Beta ± SE?=?0.104?±?0.014, P?=?4.40?×?10-?11), higher level of HOMA-IR (Beta ± SE?=?0.016?±?0.004, P?=?9.55?×?10-?5), HOMA-B (Beta ± SE?=?0.008?±?0.003, P?=?0.020). Using MR analyses, increased protein intake was causally associated with an increased risk of T2DM (Beta ± SE?=?0.806?±?0.260, P?=?0.002). In addition, smoking cessation was causally associated with increased levels of glycemic traits such as HOMA-IR (Beta ± SE?=?0.165?±?0.072, P?=?0.021), fasting insulin (Beta ± SE?=?0.132?±?0.066, P?=?0.047) and fasting glucose (Beta ± SE?=?0.132?±?0.064, P?=?0.039).These results provide evidence supporting a causal role for higher protein intake and smoking cession in T2DM. Our study provides further rationale for individuals at risk for diabetes to keep healthy lifestyle.

SUBMITTER: Ding R 

PROVIDER: S-EPMC5787924 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study.

Ding Renyu R   Huang Tao T   Han Jiali J  

Lipids in health and disease 20180129 1


<h4>Background</h4>Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.<h4>Methods</h4>A two-sample MR approach was used to examine the causal effect of diet/lifestyle upon risk of T2DM and glycemic traits.<h4>Results</h4>The protein intake-increasing allele C of FTO was significant associated with higher risk of T2DM (Beta ± SE = 0.104 ± 0.014, P = 4.40 × 10<sup>- 11</sup>)  ...[more]

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