Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5788481 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Chen Jixiang J Sun Yaocheng Y Xu Xiao X Wang Dawei D He Junbo J Zhou Hailang H Lu Ying Y Zeng Jian J Du Fengyi F Gong Aihua A Xu Min M
Cell cycle (Georgetown, Tex.) 20171114 23
Recent studies show that YTH domain family 2 (YTHDF2) preferentially binds to m<sup>6</sup>A-containing mRNA regulates localization and stability of the bound mRNA. However, the role of YTHDF2 in pancreatic cancers remains to be elucidated. Here, we find that YTHDF2 expression is up-regulated in pancreatic cancer tissues compared with normal tissues at both mRNA and protein levels, and is higher in clinical patients with later stages of pancreatic cancer, indicating that YTHDF2 possesses potenti ...[more]