Ontology highlight
ABSTRACT:
SUBMITTER: Kerwin SK
PROVIDER: S-EPMC5788533 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kerwin Sarah K SK Li Joshua Shing Shun JSS Noakes Peter G PG Shin Grace Ji-Eun GJ Millard S Sean SS
Genetics 20171205 2
How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In <i>Drosophila</i>, photoreceptors form a synapse with multiple postsynaptic elements including lamina neurons L1 and L2. L1 and L2 express distinct isoforms of the homophilic repulsive protein D ...[more]