Ontology highlight
ABSTRACT:
SUBMITTER: Tricoli L
PROVIDER: S-EPMC5788632 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Tricoli Lucas L Naeem Aisha A Parasido Erika E Mikhaiel John P JP Choudhry Muhammad Umer MU Berry Deborah L DL Abdelgawad Iman A IA Lee Richard J RJ Feldman Adam S AS Ihemelandu Chukwuemeka C Avantaggiati Maria M Kumar Deepak D Byers Stephen S Gallagher Rosa R Wulfkuhle Julia J Petricoin Emanuel E Rodriguez Olga O Albanese Chris C
Oncotarget 20171218 2
The inability to propagate human prostate epithelial cells indefinitely has historically presented a serious impediment to prostate cancer research. The conditionally reprogrammed cell (CRC) approach uses the combination of irradiated J2 mouse fibroblasts and a Rho kinase inhibitor such as Y27632 to support the continuous culture of cells derived from most epithelial tissues, including the prostate. Due to their rapid establishment and overall ease of use, CRCs are now widely used in a variety o ...[more]