Ontology highlight
ABSTRACT:
SUBMITTER: Correa BRS
PROVIDER: S-EPMC5840339 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Correa Bruna R S BRS Hu Joanna J Penalva Luiz O F LOF Schlegel Richard R Rimm David L DL Galante Pedro A F PAF Agarwal Seema S
Scientific reports 20180306 1
Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target identification and drug discovery efforts. For any model to be clinically relevant, it needs to recapitulate the biology and cell heterogeneity of the primary tumor. We recently developed and described a conditional reprogramming (CR) cell technology that addresses many of these needs and avoids the deficiencies of most current cancer cell lines, whic ...[more]