Ontology highlight
ABSTRACT:
SUBMITTER: Fujishima K
PROVIDER: S-EPMC5788988 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Fujishima Kosuke K Wang Kendrick M KM Palmer Jesse A JA Abe Nozomi N Nakahigashi Kenji K Endy Drew D Rothschild Lynn J LJ
Scientific reports 20180129 1
Amino acid biosynthesis pathways observed in nature typically require enzymes that are made with the amino acids they produce. For example, Escherichia coli produces cysteine from serine via two enzymes that contain cysteine: serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). To solve this chicken-and-egg problem, we substituted alternate amino acids in CysE, CysK and CysM for cysteine and methionine, which are the only two sulfur-containing proteinogenic amino acids. ...[more]