Ontology highlight
ABSTRACT:
SUBMITTER: Tenno M
PROVIDER: S-EPMC5789415 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Tenno Mari M Kojo Satoshi S Lawir Divine-Fondzenyuy DF Hess Isabell I Shiroguchi Katsuyuki K Ebihara Takashi T Endo Takaho A TA Muroi Sawako S Satoh Rumi R Kawamoto Hiroshi H Boehm Thomas T Taniuchi Ichiro I
The Journal of experimental medicine 20180117 2
Multipotent hematopoietic progenitors must acquire thymus-homing capacity to initiate T lymphocyte development. Despite its importance, the transcriptional program underlying this process remains elusive. Cbfβ forms transcription factor complexes with Runx proteins, and here we show that Cbfβ2, encoded by an RNA splice variant of the <i>Cbfb</i> gene, is essential for extrathymic differentiation of T cell progenitors. Furthermore, Cbfβ2 endows extrathymic progenitors with thymus-homing capacity ...[more]