Ontology highlight
ABSTRACT:
SUBMITTER: Zeng J
PROVIDER: S-EPMC7417590 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zeng Junwei J Eljalby Mahmoud M Aryal Rajindra P RP Lehoux Sylvain S Stavenhagen Kathrin K Kudelka Matthew R MR Wang Yingchun Y Wang Jianmei J Ju Tongzhong T von Andrian Ulrich H UH Cummings Richard D RD
Nature communications 20200810 1
The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induces developmental blocks of mouse B cells. After transfer into wild-type recipient, Cosmc-null B cells fail to home to lymph nodes as well as non-lymphoid organs. Enzymatic desialylation of wild-type B cells blocks their migration into lymph nodes, indicating a requ ...[more]