Ontology highlight
ABSTRACT:
SUBMITTER: Moinova HR
PROVIDER: S-EPMC5789768 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Moinova Helen R HR LaFramboise Thomas T Lutterbaugh James D JD Chandar Apoorva Krishna AK Dumot John J Faulx Ashley A Brock Wendy W De la Cruz Cabrera Omar O Guda Kishore K Barnholtz-Sloan Jill S JS Iyer Prasad G PG Canto Marcia I MI Wang Jean S JS Shaheen Nicholas J NJ Thota Prashanti N PN Willis Joseph E JE Chak Amitabh A Markowitz Sanford D SD
Science translational medicine 20180101 424
We report a biomarker-based non-endoscopic method for detecting Barrett's esophagus (BE) based on detecting methylated DNAs retrieved via a swallowable balloon-based esophageal sampling device. BE is the precursor of, and a major recognized risk factor for, developing esophageal adenocarcinoma. Endoscopy, the current standard for BE detection, is not cost-effective for population screening. We performed genome-wide screening to ascertain regions targeted for recurrent aberrant cytosine methylati ...[more]