Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Miro M
PROVIDER: S-EPMC5789850 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
González-Miró Majela M Rodríguez-Noda Laura M LM Fariñas-Medina Mildrey M Cedré-Marrero Barbara B Madariaga-Zarza Sandra S Zayas-Vignier Caridad C Hernández-Cedeño Mabel M Kleffmann Torsten T García-Rivera Dagmar D Vérez-Bencomo Vicente V Rehm Bernd H A BHA
Scientific reports 20180130 1
The efficacy of protein and carbohydrate antigens as vaccines can be improved via particulate delivery strategies. Here, protein and carbohydrate antigens used in formulations of vaccines against Neisseria menigitidis were displayed on in vivo assembled polyester beads using a combined bioengineering and conjugation approach. An endotoxin-free mutant of Escherichia coli was engineered to produce translational fusions of antigens (Neisseria adhesin A (NadA) and factor H binding protein (fHbp) der ...[more]