Ontology highlight
ABSTRACT:
SUBMITTER: Tavares ABMLA
PROVIDER: S-EPMC5789983 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Tavares Ana Beatriz M L A ABMLA Lima Neto José X JX Fulco Umberto L UL Albuquerque Eudenilson L EL
Scientific reports 20180130 1
Much of the recent excitement in the cancer immunotherapy approach has been generated by the recognition that immune checkpoint proteins, like the receptor PD-1, can be blocked by antibody-based drugs with profound effects. Promising clinical data have already been released pointing to the efficiency of the drug pembrolizumab to block the PD-1 pathway, triggering the T-lymphocytes to destroy the cancer cells. Thus, a deep understanding of this drug/receptor complex is essential for the improveme ...[more]