Ontology highlight
ABSTRACT:
SUBMITTER: Shindo T
PROVIDER: S-EPMC5790365 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Oncoimmunology 20171211 3
Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed to depletion of CCR4<sup>+</sup> regulatory T cells. We previously showed that next generation sequencing enables precise analysis of the T cell receptor (TCR) repertoire, and we here used the technique to reveal the immunological dynamics in mog ...[more]