Increased Numb protein expression predicts poor clinical outcomes in esophageal squamous cell carcinoma patients.

ABSTRACT: Numb is a protein whose asymmetric segregation during cell division determines cell fate and has numerous functions relevant to multiple fields of study, including developmental neurobiology and cancer biology. Little is known about the role of Numb in esophageal squamous cell carcinoma (ESCC), the predominant histological esophageal carcinoma in Asian populations. In this study, we focused on the expression and biologic functions of Numb in the context of ESCC. From analysis of tissue microarrays with 212 patients, it was found that Numb was significantly upregulated in ESCC tissues compared with corresponding non-cancerous tissues. Kaplan-Meier survival analysis suggests that higher expression of Numb was significantly associated with a high tumor recurrence (p = 0.015) and poor overall

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5790368 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature