Unknown

Dataset Information

0

Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma.


ABSTRACT: Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with ESCC undergoing curative surgery were enrolled. The relationship between PDW and clinical features in ESCC was analyzed using chi-square tests. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value. Overall survival (OS) and disease-free survival (DFS) stratified by PDW were evaluated by Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression were used to evaluate the prognostic effect of PDW. Of the 495 patients, elevated PDW was observed in 241(48.7%) of the patients, respectively. An elevated PDW was correlated with depth of tumor (T stage, P?=?0.031), nerve infiltration (P?=?0.016), hospital time after operation (P?=?0.020), platelet (P?

SUBMITTER: Song Q 

PROVIDER: S-EPMC6811575 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma.

Song Qian Q   Wu Jun-Zhou JZ   Wang Sheng S   Chen Wen-Hu WH  

Scientific reports 20191023 1


Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with  ...[more]

Similar Datasets

| S-EPMC5564632 | biostudies-other
| S-EPMC4021515 | biostudies-literature
| S-EPMC7178594 | biostudies-literature
| S-EPMC5323152 | biostudies-literature
| S-EPMC3387636 | biostudies-literature
| S-EPMC9264607 | biostudies-literature
| S-EPMC8137088 | biostudies-literature
| S-EPMC6001627 | biostudies-literature
| S-EPMC5386756 | biostudies-literature
| S-EPMC7367742 | biostudies-literature