Ontology highlight
ABSTRACT:
SUBMITTER: Guo B
PROVIDER: S-EPMC5791050 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Guo Bing B Lyu Qing Q Slivano Orazio J OJ Dirkx Ronald R Christie Christine K CK Czyzyk Jan J Hezel Aram F AF Gharavi Ali G AG Small Eric M EM Miano Joseph M JM
Journal of the American Society of Nephrology : JASN 20171107 2
Podocytes contain an intricate actin cytoskeleton that is essential for the specialized function of this cell type in renal filtration. Serum response factor (SRF) is a master transcription factor for the actin cytoskeleton, but the <i>in vivo</i> expression and function of SRF in podocytes are unknown. We found that SRF protein colocalizes with podocyte markers in human and mouse kidneys. Compared with littermate controls, mice in which the <i>Srf</i> gene was conditionally inactivated with <i> ...[more]