Ontology highlight
ABSTRACT:
SUBMITTER: Smith JM
PROVIDER: S-EPMC5792189 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Smith Joel M JM Qin Tian T Merchant Rohan R RR Edwards Jacob T JT Malins Lara R LR Liu Zhiqing Z Che Guanda G Shen Zichao Z Shaw Scott A SA Eastgate Martin D MD Baran Phil S PS
Angewandte Chemie (International ed. in English) 20170801 39
The development of a new decarboxylative cross-coupling method that affords terminal and substituted alkynes from various carboxylic acids is described using both nickel- and iron-based catalysts. The use of N-hydroxytetrachlorophthalimide (TCNHPI) esters is crucial to the success of the transformation, and the reaction is amenable to in situ carboxylic acid activation. Additionally, an inexpensive, commercially available alkyne source is employed in this formal homologation process that serves ...[more]