Ontology highlight
ABSTRACT:
SUBMITTER: Coleman J
PROVIDER: S-EPMC5792450 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell reports 20180101 3
Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reconstituted single vesicle and bulk fusion assays, combined with live cell imaging of single exocytotic events in PC12 cells and biophysical analysis, to delineate the physiological role of PRRT2. We re ...[more]