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Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.

ABSTRACT: A new ?-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor ?B ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1-5 had no anti-proliferative effect on human cancer cell lines up to 30 ?g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 ?g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity.

SUBMITTER: Shin HJ 

PROVIDER: S-EPMC5793062 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.

Shin Hee Jae HJ   Choi Byeoung-Kyu BK   Trinh Phan Thi Hoai PTH   Lee Hwa-Sun HS   Kang Jong Soon JS   Van Tran Thi Thanh TTT   Lee Hyi-Seung HS   Lee Jong Seok JS   Lee Yeon-Ju YJ   Lee Jihoon J  

Marine drugs 20180105 1

A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (<b>1</b>), and four known secondary metabolites, aspertetranone D (<b>2</b>), cycloechinulin (<b>3</b>), wasabidienone E (<b>4</b>), and mactanamide (<b>5</b>), were isolated from the marine fungus <i>Aspergillus flocculosus</i> derived from a sponge <i>Stylissa</i> sp. collected in Vietnam. The structures of Compounds <b>1</b>-<b>5</b> were elucidated by analysis of 1D and 2D NMR spectra and MS  ...[more]

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