Ontology highlight
ABSTRACT:
SUBMITTER: Schorning K
PROVIDER: S-EPMC5793717 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Schorning K K Dette H H Kettelhake K K Wong W K WK Bretz F F
Biometrika 20171009 4
We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boundary points of the design space are included in the optimal design. We provide an analytical description of minimally supported optimal designs and show that they do not depend on the correlation betw ...[more]