Ontology highlight
ABSTRACT:
SUBMITTER: Glatzel DK
PROVIDER: S-EPMC5794424 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Glatzel Daniel K DK Koeberle Andreas A Pein Helmut H Löser Konstantin K Stark Anna A Keksel Nelli N Werz Oliver O Müller Rolf R Bischoff Iris I Fürst Robert R
Journal of lipid research 20171205 2
The enzyme acetyl-CoA carboxylase (ACC) plays a crucial role in fatty acid metabolism. In recent years, ACC has been recognized as a promising drug target for treating different diseases. However, the role of ACC in vascular endothelial cells (ECs) has been neglected so far. To characterize the role of ACC, we used the ACC inhibitor, soraphen A, as a chemical tool, and also a gene silencing approach. We found that ACC1 was the predominant isoform in human umbilical vein ECs as well as in human m ...[more]