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S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.

ABSTRACT: S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and the disturbance in transmethylation pathways. Also included in this review are the present-day applications of SAMe in the treatment in these diseases in each age group.

SUBMITTER: Gao J

PROVIDER: S-EPMC5794704 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.

Gao Jin J Cahill Catherine M CM Huang Xudong X Roffman Joshua L JL Lamon-Fava Stefania S Fava Maurizio M Mischoulon David D Rogers Jack T JT

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20180101 1

S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and t ...[more]

PMID: 29340929

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