Ontology highlight
ABSTRACT:
SUBMITTER: Steketee PC
PROVIDER: S-EPMC5976210 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Steketee Pieter C PC Vincent Isabel M IM Achcar Fiona F Giordani Federica F Kim Dong-Hyun DH Creek Darren J DJ Freund Yvonne Y Jacobs Robert R Rattigan Kevin K Horn David D Field Mark C MC MacLeod Annette A Barrett Michael P MP
PLoS neglected tropical diseases 20180514 5
The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addition, there is emerging evidence for drug resistance. AN5568 (SCYX-7158) is a novel benzoxaborole class compound that has been selected as a lead compound for the treatment of HAT, and has demonstrated ...[more]