Unknown

Dataset Information

0

Upfront surgery and pathological stage-based adjuvant chemoradiation strategy in locally advanced esophageal squamous cell carcinoma.


ABSTRACT: Adjuvant chemoradiation is reported to have a survival benefit for esophageal squamous cell carcinoma (ESCC). We evaluated the "upfront surgery and pathological stage-based adjuvant chemoradiation" strategy, in which adjuvant therapy is guided by pathological stage, in locally advanced ESCC. Data from 2976 clinical stage II/III ESCC patients, including 1735 in neoadjuvant chemoradiation and 1241 in upfront surgery groups, were obtained from a nationwide database. Patients in the upfront surgery group were further categorized into the "upfront surgery and pathological stage-based adjuvant chemoradiation" and "upfront surgery only" groups. The 3-year overall survival (OS) rates in the "neoadjuvant chemoradiation", "upfront surgery and pathological stage-based adjuvant chemoradiation", and "upfront surgery only" groups were 41.5%, 45.8%, and 28.5%, respectively. In propensity score matched patients, the 3-year OS rate was 41.7% in the neoadjuvant chemoradiation group, compared to 35.6% in the "upfront surgery and pathological stage-based adjuvant chemoradiation" group (p?=?0.147), and 20.3% in the "upfront surgery only" group (p?

SUBMITTER: Chen HS 

PROVIDER: S-EPMC5794775 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Upfront surgery and pathological stage-based adjuvant chemoradiation strategy in locally advanced esophageal squamous cell carcinoma.

Chen Hui-Shan HS   Hsu Po-Kuei PK   Liu Chia-Chuan CC   Wu Shiao-Chi SC  

Scientific reports 20180201 1


Adjuvant chemoradiation is reported to have a survival benefit for esophageal squamous cell carcinoma (ESCC). We evaluated the "upfront surgery and pathological stage-based adjuvant chemoradiation" strategy, in which adjuvant therapy is guided by pathological stage, in locally advanced ESCC. Data from 2976 clinical stage II/III ESCC patients, including 1735 in neoadjuvant chemoradiation and 1241 in upfront surgery groups, were obtained from a nationwide database. Patients in the upfront surgery  ...[more]

Similar Datasets

| S-EPMC9688301 | biostudies-literature
| S-EPMC9623425 | biostudies-literature
| S-EPMC5355287 | biostudies-literature
| S-EPMC9074348 | biostudies-literature
| S-EPMC11065504 | biostudies-literature
2017-03-30 | E-MTAB-5198 | biostudies-arrayexpress
| S-EPMC6105676 | biostudies-literature
| S-EPMC8319733 | biostudies-literature
| S-EPMC8533976 | biostudies-literature