Ontology highlight
ABSTRACT:
SUBMITTER: Coller KE
PROVIDER: S-EPMC5794785 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Coller Kelly E KE Butler Emily K EK Luk Ka-Cheung KC Rodgers Mary A MA Cassidy Michael M Gersch Jeffrey J McNamara Anne L AL Kuhns Mary C MC Dawson George J GJ Kaptue Lazare L Bremer Birgit B Wedemeyer Heiner H Cloherty Gavin A GA
Scientific reports 20180201 1
Worldwide, an estimated 5% of hepatitis B virus (HBV) infected people are coinfected with hepatitis delta virus (HDV). HDV infection leads to increased mortality over HBV mono-infection, yet HDV diagnostics are not widely available. Prototype molecular (RNA) and serologic (IgG) assays were developed for high-throughput testing on the Abbott m2000 and ARCHITECT systems, respectively. RNA detection was achieved through amplification of a ribozyme region target, with a limit of detection of 5 IU/ml ...[more]