Ontology highlight
ABSTRACT:
SUBMITTER: Moustafa A
PROVIDER: S-EPMC5795019 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Moustafa Ahmed A Li Weizhong W Anderson Ericka L EL Wong Emily H M EHM Dulai Parambir S PS Sandborn William J WJ Biggs William W Yooseph Shibu S Jones Marcus B MB Venter J Craig JC Nelson Karen E KE Chang John T JT Telenti Amalio A Boland Brigid S BS
Clinical and translational gastroenterology 20180118 1
<h4>Objectives</h4>Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in genetically susceptible individuals. New technologies support the joint assessment of host-microbiome interaction.<h4>Methods</h4>Using whole genome sequencing and shotgun metagenomics, we studied the clinical features, host genome, and sto ...[more]