Ontology highlight
ABSTRACT:
SUBMITTER: Kon R
PROVIDER: S-EPMC5796119 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kon Risako R Tsubota Yuika Y Minami Moe M Kato Saki S Matsunaga Yukari Y Kimura Hiroshi H Murakami Yuta Y Fujikawa Tetsuya T Sakurai Ryoya R Tomimoto Rei R Machida Yoshiaki Y Ikarashi Nobutomo N Sugiyama Kiyoshi K
International journal of molecular sciences 20180106 1
While irinotecan (CPT-11) has a potent anti-cancer effect, it also causes serious diarrhea as an adverse reaction. In this study, we analyzed the pathogenic mechanism of CPT-11-induced delayed diarrhea by focusing on water channel aquaporin-3 (AQP3) in the colon. When rats received CPT-11, the expression level of AQP3 was reduced during severe diarrhea. It was found that the expression levels of inflammatory cytokines and the loss of crypt cells were increased in the colon when CPT-11 was admini ...[more]