Unknown

Dataset Information

0

Transcriptomics Evidence for Common Pathways in Human Major Depressive Disorder and Glioblastoma.


ABSTRACT: Depression as a common complication of brain tumors. Is there a possible common pathogenesis for depression and glioma? The most serious major depressive disorder (MDD) and glioblastoma (GBM) in both diseases are studied, to explore the common pathogenesis between the two diseases. In this article, we first rely on transcriptome data to obtain reliable and useful differentially expressed genes (DEGs) by differential expression analysis. Then, we used the transcriptomics of DEGs to find out and analyze the common pathway of MDD and GBM from three directions. Finally, we determine the important biological pathways that are common to MDD and GBM by statistical knowledge. Our findings provide the first direct transcriptomic evidence that common pathway in two diseases for the common pathogenesis of the human MDD and GBM. Our results provide a new reference methods and values for the study of the pathogenesis of depression and glioblastoma.

SUBMITTER: Xie Y 

PROVIDER: S-EPMC5796182 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Transcriptomics Evidence for Common Pathways in Human Major Depressive Disorder and Glioblastoma.

Xie Yongfang Y   Wang Ling L   Xie Zengyan Z   Zeng Chuisheng C   Shu Kunxian K  

International journal of molecular sciences 20180112 1


Depression as a common complication of brain tumors. Is there a possible common pathogenesis for depression and glioma? The most serious major depressive disorder (MDD) and glioblastoma (GBM) in both diseases are studied, to explore the common pathogenesis between the two diseases. In this article, we first rely on transcriptome data to obtain reliable and useful differentially expressed genes (DEGs) by differential expression analysis. Then, we used the transcriptomics of DEGs to find out and a  ...[more]

Similar Datasets

2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
2010-10-17 | E-GEOD-24095 | biostudies-arrayexpress
2012-04-27 | E-GEOD-37579 | biostudies-arrayexpress
2011-10-05 | GSE19738 | GEO
2010-10-17 | GSE24095 | GEO
2022-05-20 | PXD028947 | Pride
| S-EPMC9893602 | biostudies-literature
| S-EPMC6389674 | biostudies-literature
| S-EPMC8803333 | biostudies-literature
| S-EPMC8502978 | biostudies-literature