Ontology highlight
ABSTRACT:
SUBMITTER: Puri S
PROVIDER: S-EPMC5797102 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Puri Sapna S Roy Nilotpal N Russ Holger A HA Leonhardt Laura L French Esra K EK Roy Ritu R Bengtsson Henrik H Scott Donald K DK Stewart Andrew F AF Hebrok Matthias M
Nature communications 20180202 1
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally immature as defined by a lower set point for glucose-stimulated insulin secretion. Here we show that β-cell proliferation and immaturity are linked by tuning expression of physiologically relevant, non-oncogenic levels of c-Myc. Adult β cel ...[more]