Ontology highlight
ABSTRACT:
SUBMITTER: Corey BW
PROVIDER: S-EPMC5798234 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Corey Brendan W BW Thompson Mitchell G MG Hittle Lauren E LE Jacobs Anna C AC Asafo-Adjei Edward A EA Huggins William M WM Melander Roberta J RJ Melander Christian C Ernst Robert K RK Zurawski Daniel V DV
ACS infectious diseases 20161103 1
Acinetobacter baumannii are Gram-negative bacilli that pose a constant threat to susceptible patients because of increased resistance to multiple antibiotics and persistence in the hospital environment. After genome analysis, we discovered that A. baumannii harbors genes that share homology to an enzymatic pathway that elongates long-chain fatty acids (LCFA) in fungi. Previously, 1,2,4-triazolidine-3-thiones (T-3-Ts) were shown to inhibit hyphae production in fungi, and this same LCFA elongation ...[more]