Ontology highlight
ABSTRACT:
SUBMITTER: Huggins WM
PROVIDER: S-EPMC5238477 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Huggins William M WM Minrovic Bradley M BM Corey Brendan W BW Jacobs Anna C AC Melander Roberta J RJ Sommer Roger D RD Zurawski Daniel V DV Melander Christian C
ACS medicinal chemistry letters 20161112 1
With only two new classes of antibiotics developed in the last 40 years, novel antibiotics are desperately needed to combat the growing problem of multidrug-resistant and extensively drug resistant bacteria, particularly Gram-negative bacteria. Described in this letter is the synthesis and antibiotic activity of 1,2,4-triazolidine-3-thiones as narrow spectrum antibiotics. Optimization of the 1,2,4-triazolidine-3-thione scaffold identified a small molecule with potent antibiotic activity against ...[more]