Ontology highlight
ABSTRACT:
SUBMITTER: Choppara S
PROVIDER: S-EPMC5798317 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Choppara Srinadh S Malonia Sunil K SK Sankaran Ganga G Green Michael R MR Santra Manas Kumar MK
Proceedings of the National Academy of Sciences of the United States of America 20180117 5
The F-box protein FBXO31 is a tumor suppressor that is encoded in 16q24.3, for which there is loss of heterozygosity in various solid tumors. FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of pivotal cell-cycle regulatory proteins including cyclin D1 and the p53 antagonist MDM2. FBXO31 levels are normally low but increase substantially following genotoxic stress through a mechanism that r ...[more]