Ontology highlight
ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC5799380 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kim Do-Hyun DH Park Hong-Jai HJ Lim Sangho S Koo Ja-Hyun JH Lee Hong-Gyun HG Choi Jin Ouk JO Oh Ji Hoon JH Ha Sang-Jun SJ Kang Min-Jong MJ Lee Chang-Min CM Lee Chun Geun CG Elias Jack A JA Choi Je-Min JM
Nature communications 20180205 1
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tum ...[more]