Chitinase-like proteins in lung injury, repair, and metastasis.
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ABSTRACT:
SUBMITTER: Lee CG
PROVIDER: S-EPMC3359113 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Chitinase-like proteins in lung injury, repair, and metastasis.
Lee Chun Geun CG Dela Cruz Charles S CS Ma Bing B Ahangari Farida F Zhou Yang Y Halaban Ruth R Sznol Mario M Elias Jack A JA
Proceedings of the American Thoracic Society 20120501 2
This report explains how our studies of asthma and Th2 inflammation led us to investigate the roles of chitinase-like proteins (CLPs) in lung injury and repair and puts forth an overall hypothesis that can explain the roles that these moieties play in biology and a hypothesis regarding the ways that dysregulated CLP expression may contribute to the pathogenesis of a variety of diseases. We test this hypothesis by assessing the contributions of the CLP breast regression protein (BRP)-39 in the pa ...[more]
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