A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors.
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ABSTRACT:
SUBMITTER: Kohli J
PROVIDER: S-EPMC5800901 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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A novel suicide gene therapy for the treatment of p16<sup>Ink4a</sup>-overexpressing tumors.
Kohli Jaskaren J Campisi Judith J Demaria Marco M
Oncotarget 20171228 7
p16<sup>Ink4a</sup> is a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. However, in tumors carrying mutations in key downstream effectors, p16<sup>Ink4a</sup> is highly expressed but fails to block cell proliferation. p16<sup>Ink4a</sup>-overexpressing tumor cells are highly aggressive and no targeted interventions are available. To study the effect of specific therapies, we generated murine sarcomas by overexpressing RAS oncogene and disrupting p53 ...[more]
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