Ontology highlight
ABSTRACT:
SUBMITTER: Janssens S
PROVIDER: S-EPMC5801341 | biostudies-literature | 2018 Jan-Feb
REPOSITORIES: biostudies-literature
Janssens Sylvie S Schotsaert Michael M Karnik Rahul R Balasubramaniam Vinod V Dejosez Marion M Meissner Alexander A García-Sastre Adolfo A Zwaka Thomas P TP
mSystems 20180101 1
Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based on embryonic stem cell-derived brain organoids, we studied the impact of ZIKV infection on the DNA methylation pattern across the entire genome in selected neural cell types. The virus unexpectedly alters the DNA methylome of neural progenitors, astrocytes, an ...[more]