A polygenic score for schizophrenia predicts glycemic control.
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ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC5802590 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
A polygenic score for schizophrenia predicts glycemic control.
Cao Han H Chen Junfang J Meyer-Lindenberg Andreas A Schwarz Emanuel E
Translational psychiatry 20171218 12
Schizophrenia is substantially comorbid with type 2 diabetes (T2D), but the molecular basis of this effect is incompletely understood. Here, we show that a cortical schizophrenia expression score predicts glycemic control from pancreatic islet cell expression. We used machine learning to identify a cortical expression signature in 212 schizophrenia patients and controls, which explained ~25% of the illness-associated variance. The algorithm was predicted in expression data from 51 subjects (9 wi ...[more]
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