A polygenic score for age-at-first-birth predicts disinhibition.

ABSTRACT:

Background

A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition.

Methods

We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Dunedin Study (N = 918). We calculated a genome-wide polygenic score for age-at-first-birth and tested whether it was associated with a range of disinhibitory outcomes across the life course, including low childhood self-control; risk for externalizing psychopathology; officially recorded

SUBMITTER: Richmond-Rakerd LS 

PROVIDER: S-EPMC7529719 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature