Ontology highlight
ABSTRACT:
SUBMITTER: Lynch DL
PROVIDER: S-EPMC5802876 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lynch Diane L DL Hurst Dow P DP Shore Derek M DM Pitman Mike C MC Reggio Patricia H PH
Methods in enzymology 20170704
The cannabinoid type 1 and 2 G-protein-coupled receptors are currently important pharmacological targets with significant drug discovery potential. These receptors have been shown to display functional selectivity or biased agonism, a property currently thought to have substantial therapeutic potential. Although recent advances in crystallization techniques have provided a wealth of structural information about this important class of membrane-embedded proteins, these structures lack dynamical i ...[more]