Ontology highlight
ABSTRACT:
SUBMITTER: Jung SW
PROVIDER: S-EPMC6137198 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jung Sang Won SW Cho Art E AE Yu Wookyung W
Scientific reports 20180913 1
Cannabinoid receptor 1 (CB1) is a promising therapeutic target for a variety of disorders. Distinct efficacy profiles showed different therapeutic effects on CB1 dependent on three classes of ligands: agonists, antagonists, and inverse agonists. To discriminate the distinct efficacy profiles of the ligands, we carried out molecular dynamics (MD) simulations to identify the dynamic behaviors of inactive and active conformations of CB1 structures with the ligands. In addition, the molecular mechan ...[more]