Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XJ
PROVIDER: S-EPMC5803243 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhang Xing-Jie XJ Wang Rui-Rui RR Chen Huan H Luo Rong-Hua RH Yang Liu-Meng LM Liu Jing-Ping JP Sun Han-Dong HD Zhang Hong-Bin HB Xiao Wei-Lie WL Zheng Yong-Tang YT
Scientific reports 20180207 1
In a previous study the small molecule SJP-L-5 that inhibits HIV replication, has been shown to block uncoating of the viral capsid. Continued study showed that SJP-L-5 might hinder HIV capsid uncoating by blocking the completion of reverse transcription. However, to date, the mechanism has not been fully elucidated. Here, the effects of SJP-L-5 for reverse transcription were explored via quantitative PCR, DIG-labelled ELISA, fluorescent resonance energy transfer, and Southern blot assays. We al ...[more]