Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice.
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ABSTRACT:
SUBMITTER: Bohacek J
PROVIDER: S-EPMC5804514 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Probing the germline-dependence of epigenetic inheritance using artificial insemination in mice.
Bohacek Johannes J von Werdt Sarah S Mansuy Isabelle M IM
Environmental epigenetics 20160101 1
We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, <i>in vitro</i> culture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspri ...[more]
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