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Bromofluorination of Unsaturated Compounds using DMPU/HF as a Fluorinating Reagent.

ABSTRACT: Bromofluorination reactions were performed by treating of a variety of unsaturated compounds with N-bromosuccinimide (NBS) and DMPU/HF as the fluorinating reagent. The DMPU/HF complex showed to be an efficient fluorinating reagent to convert alkenes into their corresponding bromofluoro compounds. It showed to have high reactivity and the process afforded bromofluorinated products with good Markovnikov regioselectivity. These fluorinated compounds are useful starting materials and serve as building blocks for many fluorinated biologically active molecules.

SUBMITTER: Liang S

PROVIDER: S-EPMC5804895 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Bromofluorination of Unsaturated Compounds using DMPU/HF as a Fluorinating Reagent.

Liang Shengzong S Barrios Francis J FJ Okoromoba Otome E OE Hetman Zofia Z Xu Bo B Hammond Gerald B GB

Journal of fluorine chemistry 20170804

Bromofluorination reactions were performed by treating of a variety of unsaturated compounds with N-bromosuccinimide (NBS) and DMPU/HF as the fluorinating reagent. The DMPU/HF complex showed to be an efficient fluorinating reagent to convert alkenes into their corresponding bromofluoro compounds. It showed to have high reactivity and the process afforded bromofluorinated products with good Markovnikov regioselectivity. These fluorinated compounds are useful starting materials and serve as buildi ...[more]

PMID: 29430062

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