Ontology highlight
ABSTRACT:
SUBMITTER: Okoromoba OE
PROVIDER: S-EPMC5381514 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Okoromoba Otome E OE Hammond Gerald B GB Xu Bo B
Organic letters 20150811 16
DMPU/HF (HF content 65 wt %/wt) is an ideal nucleophilic fluorination reagent for the diastereoselective synthesis of substituted 4-fluorotetrahydropyrans and 4-fluoropiperidines via a fluoro-Prins reaction. When compared to classical nucleophilic fluorination reagents like pyridine/HF, DMPU/HF gives both higher yields and better diastereoselectivity. ...[more]