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Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa.


ABSTRACT: We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of the amplified products.

SUBMITTER: Antinori S 

PROVIDER: S-EPMC5805056 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa.

Antinori Spinello S   Tonello Cristina C   Edouard Sophie S   Parravicini Carlo C   Gastaldi Daniela D   Grande Romualdo R   Milazzo Laura L   Ricaboni Davide D   Fenollar Florence F   Raoult Didier D   Corbellino Mario M   Mediannikov Oleg O  

The American journal of tropical medicine and hygiene 20170921 6


We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of  ...[more]

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