Ontology highlight
ABSTRACT:
SUBMITTER: Plenker D
PROVIDER: S-EPMC5805089 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Science translational medicine 20170601 394
Oncogenic fusion events have been identified in a broad range of tumors. Among them, <i>RET</i> rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide further evidence that current anti-RET drugs may not be potent enough to induce durable responses in such tumors. We report that potent inhibitors, such as AD80 or ponatinib, that stably bind in the DFG-out conformation of RET may overcome these limitations and selectively ...[more]