Ontology highlight
ABSTRACT:
SUBMITTER: Mok HP
PROVIDER: S-EPMC5805784 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Mok Hoi Ping HP Norton Nicholas J NJ Hirst Jack C JC Fun Axel A Bandara Mikaila M Wills Mark R MR Lever Andrew M L AML
Scientific reports 20180208 1
The persistence of infected T cells harbouring intact HIV proviruses is the barrier to the eradication of HIV. This reservoir is stable over long periods of time despite antiretroviral therapy. There has been controversy on whether low level viral replication is occurring at sanctuary sites periodically reseeding infected cells into the latent reservoir to account its durability. To study viral evolution in a physiologically relevant population of latent viruses, we repeatedly performed virus ou ...[more]