Ontology highlight
ABSTRACT:
SUBMITTER: Jain S
PROVIDER: S-EPMC5807958 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Jain Shweta S Ward Jerrold M JM Shin Dong-Mi DM Wang Hongsheng H Naghashfar Zohreh Z Kovalchuk Alexander L AL Morse Herbert C HC
The American journal of pathology 20170717 9
A number of mouse strains transgenic for B-cell receptors specific for nucleic acids or other autoantigens have been generated to understand how autoreactive B cells are regulated in normal and autoimmune mice. Previous studies of nonautoimmune C57BL/6 mice heterozygous for both the IgH and IgL knockins of the polyreactive autoantibody, 564, produced high levels of autoantibodies in a largely Toll-like receptor 7-dependent manner. Herein, we describe studies of mice homozygous for the knockins t ...[more]